"At what point in the draw cycle do you operate the safety on a 1911? Is it only right before pressing the trigger, once sights are fully aligned, or do you do it at point 3 of the draw (through the press out)?"
I was addressing the subject in the context of the OP's question and I used the term "presentation" deliberately. I would think it goes without saying that there are a host of reasons you would manipulate the safety differently if you weren't presenting the gun to the target with the intentions of firing.
I apologize if I wasn't clear with my response.