Originally Posted by
Thn9mm
The risk of biologics to major organs (heart, liver, kidneys) is low, that is we have not seen it yet (not saying that we will). The main risk of biologics, depending on their effects on the immune system, is an increased risk of serious infections and cancer. All biologics affect the immune system but some do so broadly, while others are more specific. Humira has a broad effect, therefore it requires more monitoring and has more risks for serious infections and cancer. Cosentyx and others like it is more specific, and therefore requires almost no monitoring and does not carry the black box warning like Humira. Think shotgun vs AR with 1-6X variable optic rifle. Humira is shotgun approach and COsentyx is AR with scope.