Isn't it interesting how shooting someone else's problem in a match, or even a course, shows up technique or equipment imperfections that have gone unnoticed in your own practice. Same with actual big game hunting as opposed to practicing for hunting. No doubt, SeanM would have many examples of crap rearing its ugly head when people are shooting back at you.
Partially this is technique. I don't have BUIS on either the Q5 or Glock MOS pistols that I shoot in USPSA. Other than the DP Pro turning off, I have not had many issues finding the dot, although I try to frame the target using the whole lens of the DP Pro, and that brings the dot to me reliably. For EDC, BUIS or a laser would be better yet, then relying solely on technique.
I have tried to shoot with the dot off, and the DP Pro lens is so wide, the results are abysmal -- so I would bet against hitting the eight inch steel at 20 yards using solely index. Even if fleeting, I really do need to see the a bit of the dot, and do with draws down into the low .50's.
I wish there was a reliable, unobtrusive, easy (but not too easy) to activate green laser for every pistol I have. When I tore a retina four years or so ago, my right eye was unusable for a few weeks, and a laser allows either eye to work. Shooting field courses at night with a green laser feels like cheating.