Regarding .22 v. .25, the point about picking the right ammo is a good one. I have watched .25 ammo penetrate a wooden target frame about 3/16 inch, and then drop to the ground undamaged. A .22 from my North American Arms mini revolver will bury itself completely in the same wood, from essentially the same barrel length (rifled portion only). This observation, as well as the relative cost of practice ammo, has caused me to prefer the .22.
A Kel-Tec P-32 provides a more potent option than either with comfortable recoil, but some individual circumstances will call for a .22. This is what prompted Claude Werner's "old man gun" concept.
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