Let's not forget penetration. Our large or small diameter bullet must be able to reach vital organs and major blood vessels.
Our small 9mm that penetrates through to the heart will outperform our 44SPL with a soft lead bullet that breaks apart after hitting ribs or other bones.
Tissue disruption won't really matter unless the tissue being disrupted is directly related to the CNS. At least not for rapid incapacitation. Dying a week after from infection or renal failure doesn't count.
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