Caspian has had for years a vertical bump grip safety,
https://www.caspianarms.com/product-.../grip-safeties
Pretty much wherever your palm hits that sucker, it'll deactivate the safety. I've always been a bit surprised that they didn't gain more market traction in the 1911 world; SIG-Sauer had them for several years as the OEM grip safety on their GSR/1911 line, but eventually they too went to the more commonplace horizontal memory/speed bump.
I have it on my Gen 2 GSR XO, and I've always been very pleased with it. Some 1911 purists consider it to be aesthetically challenged, but I'm a "function over style" kinda 1911 user.
Best, Jon