I use the full guard with my Commander and have no serious issues. In fact there is a part of the holster that serves as a nice index for where I place my thumb when I grip the pistol before drawing. But when holstering I cannot keep upward pressure on the safety with my thumb and have to trust the holster to do that -- which it does.
If I order another holster I might get it with the middle or no guard to see if it changes the above.