I should also note that I believe that the reason I experienced an accuracy and consistency increase with the addition of the RMRs is largely due to the way my eyes interact with the front sight. I use prescription lenses full time and have an astigmatism as well as scarring on my right eye. My eyesight started noticeably deteriorating a few years ago. The result is that even with prescription lenses and full daylight, I do not have the ability to intensely focus on my front sight for more than 1-2 seconds without my eyes going haywire and causing the image to go into and out of focus multiple times or to switch focus to things in the foreground or background, namely either the target or the rear sight notch.
I can still shoot Irons fairly well. Last range session I turned in several 4.6 and one 4.4 clean runs for the FAST and a 94 on a 10rd B8 string at 25, with my G17 with Dawson sights. However it requires significantly more effort on my part in order to turn in a performance like that, and it's not something I can replicate all day long because it requires more cognitive effort than shooting with an RMR does. The front sight was also slightly blurry for the FAST runs, and I was using the red fiber optic as a pseudo red dot and maintained a target focus the entire time.
It's my opinion that the RMR was beneficial to me because I am no longer asking my eyes to do something that is physically difficult for them (focus on the front sight for extended periods of time), combined with the ability to get the optic precisely zeroed, and the target focused nature of using an RDS (focusing on the target is not an issue for me). Anecdotally, I've noticed that it requires much less effort to achieve the same, or greater, levels of accuracy at distance, as well as accuracy while shooting SHO/WHO.
The only downsides to RMR use that I have identified so far have been a reduction in speed while shooting SHO/WHO, the optic's parallax, and the fact that with a cheek/neck index handheld lighting technique (my preferred technique), you have to be very meticulous with setting dot brightness. In my experience, if the dot is not centered in the window, you will experience a POI shift. For an easy reference, when shooting the head portion of the FAST, if the dot is towards the top of the 3x5, and the top of the RMR window, my rounds impact towards the bottom of the 3x5.
You'll need to experiment in order to achieve a useable dot that is neither washed out by the handheld light or so bright that the glare occludes sighting through the lens. For my RM07, this means I have to manually set the brightness to 3 positions down from the max when it starts to get dark, and my RM06 is 2 positions down from the max. The auto adjust setting works fine the majority of the time, and in my experience it will adjust to the light coming from the cheek/neck index, however if I use my WML (TLR-1 HL) it will not adjust and trying to use the dot becomes more trouble than it's worth. With the brightness settings mentioned above, I'm able to use either WML, or handheld in a low light/no light setting, as well as maintain a useable dot should I walk indoors into a brightly lit setting (my house, gas station, grocery store etc.) The setting is not sufficient for use during bright sunlight, which is when I will resort to the auto adjust feature. This is why I suggested in the conclusion that in my opinion, RDS use on carry guns require a dedicated user, similar to Hilton Yam's thoughts on users of 1911s.
I'll continue to update this thread periodically with more findings and my experiences with RDS on pistols. Hopefully this can help serve to educate those on the fence about the pros and cons for RDS usage on defensive pistols.