Super tough guys is one thing in the age of drone and precision artillery...what about supersmart?
Go at AI via the meat route.
If you've read Peter Watts Blindsight, he posits genetically resurrected vampires-apex predators of Homo Sapiens. Able to out-think us in umpteen dimensions.
Richard Morgan did a post Human protagonist in Thirteen, Supersoldier, supersmart, utterly without compunction.
The next century or so is gonna be rough sledding for humanity.