[QUOTE=Wheeler;1325937]
Yes there definitely is.
Outside of handloading you are extremely unlikely to find any Schofield ammo (aka .45 S&W) loaded beyond old black powder levels, even when using modern propellants. This has to do with the types of revolvers that chambered the cartridge, such as the old S&W Model 3, which was a top break revolver.
The .45 Colt, aka Long Colt however, is an entirely different animal.
Modern ammunition can be, and is loaded from very sedate, black powder era levels to levels that equal, and sometimes can exceed that of top end .44 Magnum type loads. Manufacturers such as Starline produce .45 Colt brass to handle similar pressures as .44 Magnum brass. Given that it is simply a matter of case volume (the .45 Colt case has more internal volume than the Schofield), you can put more powder in it, when using a projectile of equal weight.
Here is a pic of the Schofield case and .45 Colt case, side by side, both cases of the same manufacturer (Starline).
A simple way to compare the two, would be similar to a .38 Special case and a .357 Magnum, with the .45 Colt representing the .357 Magnum.
And a .45 Cowboy Special, .45 S&W Schofield, and .45 Colt/Long Colt.
Hope this helps some readers.