It is my first choice for packing meat, backing up my wife on bear, and for her backing me up. There are numerous people in Alaska, probably even out there this minute, hunting bear, moose in thick cover, and even deer with Guide Guns. I would be surprised if there is a single person out there now, hunting with a shotgun.
At the Gunsite Backcountry course, which was designed for gov't field workers in bear country, the two long gun school solutions are the shotgun and .45-70 lever gun. As I said previously, 25 yards and in, I would take a M2, and beyond that, the Guide Gun. It really gets down to personal preference and your assessment of the challenge.