.45s don't need to expand, or super high velocity to kill. They have been putting both large animals and people into the dirt for over a century, without the need for any expansion.
We have been wrapped up in the whole 9mm is now equal to everything else silliness for a good little bit now and the more it gets read and repeated, the more it is believed. Funny, you don't see the experienced handgun hunters deliberately trading in their .45 Colt and .44 Magnums for 9x19s..
Back to the Jovino,
With a proper handload, it is just as effective today at dropping whatever needs dropped as it has ever been. Heavy slugs are VERY hard to stop and penetrate deep.
Here is a pic of a friend who killed this cow elk a few years back using an old M1917 .45 ACP revolver and .45 Auto Rim brass. The bullets were 246.5 grains with a velocity of 900 FPS. Obviously, it worked.
John Linebaugh, who is well known in the handgun building community for making hunting guns has this to say:
I have personally taken about 10 antelope and 1 mule deer with a .45 Colt. My boys have taken around 6 antelope and 5 mule deer with their .45 Colts. They use a 4 3/4" Colt SA and the handload is a 260 Keith cast at 900 fps. This load will shoot lengthwise of antelope and mule deer at 100 yards.
That is not particularly heavy load and one that is easily achievable in a shorter barrel. I run a similar load in my 4& 5/8ths" Flattop single action using 270 grain wide meplat SWCs.
In summary, .45s don't need expansion to work. With proper loads, generally utilizing a heavy projectile, they break bones and give complete penetration. It has been working since the days when men rode horses and carried handguns stuffed with black powder.