Lock up and end shake are easy.
Unload, then triple check to make sure it didn't magically reload itself.
Close the cylinder, cock the revolver with the hammer.
Holding the butt with one hand and the cylinder with the other, first attempt to rotate the cylinder. There should be a little play but not excessive.
Then attempt to move the cylinder back and forth between the recoil shield and the forcing cone. If there's more than a couple thousandths of movement you have an endshake issue.
Repeat with the other five cylinders.
Timing is a bit more involved in that you need a properly sized dowel that will fit snugly in the muzzle and slide the length of the bore and into the cylinder.
Once again with the pistol cocked in single action, slide the dowel down the bore, through the forcing cone and into the cylinder. If the dowel is stopped by one edge of the cylinder, you have a timing issue.
An alternative is to shine a light through the cylinder to forcing cone gap and use the Mark 1, Mod 2 eyeball to see if you can see part of the cylinder while looking down the bore. It's field expedient but not nearly as accurate as the dowel method.
Once again repeat with the other five cylinders.