My nightstand gun is a Gen 4 Glock 21 .45 equipped with a SureFire X300UL and loaded with Cor-Bon DPX 185-grain all-copper hollowpoints. My sights are Vickers Tactical Battle Sights (tritium front) and I keep a "go-bag" beside the bed equipped with extra G21 mags (same defensive load), Coleman LED flashlight, OC (less lethal force option), SOG folder, CAT tourniquet, and Israeli bandages. I'm considering the future purchase of a refillable cellular telephone from Wal-Mart to keep fully charged and in the go bag as a secondary comms option.
I chose the DPX round for home use though I prefer HST. Overpenetration is my concern though I know the .45 is not famous for it. The reason why I chose the DPX is that my home has classic crappy early 80s architecture with little insulation and weakly constructed interior walls. My son is located at the front of the hallway toward the French all-glass front doors. We are located back down the hallway in the master bedroom toward the back of the house. If an intrusion comes, I expect it to be at the glass doors simply because they are the easiest to breach. My first goal would be to get to my son, and if I have to shoot, I chose the DPX to minimize overpenetration concerns.
I also keep soft body armor in the bedroom for my wife and I am questioning its inclusion into my emergency plan. It may just be too much. The way I have the body armor set up is after we put it on and adjusted it to fit, we loosened the left straps (we're right handed), so that we can put it on and attach the left straps, if necessary, with our non-dominant hands. I'm open to comments and input on the soft body armor idea.
My wife's nightstand gun is a S&W 66-1 .357/.38 revolver loaded with Speer Gold Dot 135-grain +P JHPs. Her go bag is set up with 2 Safariland Comp 2 speedloaders (same defensive load), light and medical supplies as in my go bag. She also keeps her purse in the bedroom at night and it has her Ruger LCR .38 in a purse holster and it's backed up by 2 Five-Star aluminum speedloaders (excellent!) also loaded with Gold Dots.
I have my "Andrew Patti gun" at the front of the house near the glass French doors. It's hidden away but quickly accessible. It is a Glock 22 equipped with an older Streamlight M3 light loaded with Federal HST 165-grain JHPs. I keep it in condition 3 with the magazine downloaded by 1 to preserve the spring during long term storage.