Rimless cartridges which depend on easily bent sheet metal clips are not the best choice for defense. While revolvers don’t depend on grip to function, they do depend on grip for you to put enough leverage on the trigger will keep in the gun straight to actually hit anything. If this will be a carry gun, even a niche application, carry gun forget about 45 and buy the GP 100 in .38/.357.
The other issue is because there is some give or springi-ness to the sheet metal clips when the firing pin strikes the rimless rounds 45 ACP revolvers need to have slightly heavier trigger polls to ensure reliable ignition.
If you want a cool Range Gun to explore revolvers, and you happen to have a lot of 45 ACP ammo or load for 45 for your other guns a .45 revolver can be fun.
Don’t overthink it.