Doc hasn't chimed in yet on 410, so I'll regurgitate what I think I know without any supporting evidence:
410 slugs out of a shotgun are in the same ballistic range as a 357 Magnum handgun (on the high end, like Buffalo Bore loads), and fragment badly upon impact leading to low penetration.
Maybe that's a product of soft lead and a quality slug design could fix it, but even if it had harder lead you're still using a longarm to throw 90-110gr slugs downrange with the power of a hot 357 handgun. Smoke'em if ya got'em, but if buying new you might as well just buy a pistol caliber carbine instead or get a real shotgun.