Another vote for it not needing to be a big consideration. I usually get the cheapest brass cased 55gr .223 as true practice ammo, sometimes that’s AE or PMC, right now it’s Igman. I have some quality (MEN) 56gr 5.56 as the bulk defensive round. It’s not so expensive that I will feel terrible using it as basic practice ammo but since it’s slightly higher pressure, it’ll cycle the gun more reliably and reach out a little further than the .223. It also groups pretty consistently. I used this stuff in an LPVO class and was reliably hitting out to 450m. At about 550-600m, it was going subsonic and becoming unpredictable from what I remember (this was also out of a 12.5 FWIW).
For defensive use, I have a mix of 75gr Gold Dot and 77gr IMI OTM. Pre-Covid, I did have a stash of 75gr AE ball that had nearly identical POI as the GD out to at least 50, maybe even 100. It also grouped very well so I shot it at distance a few times, but it was kind of slow IIRC. That stuff has been hard to find since though.