I've owned a car or truck since 1982. Several of them had over 200K miles and most of them over 100K miles when sold. I had one that killed a head gasket at 10 years and 160K miles. Other than that I have never replaced any major driveline component and many of those years I used conventional oil.
Engines nowadays are pushed a little harder in the horsepower department and I use synthetic per the recommendation. That doesn't make me an expert but it does show my experience,- follow the manufacturer's guidelines and you shouldn't have any issues.